Endocrine Abstracts

Vitamin D role is not only associated with mineral metabolism and bone health but also in globally important diseases such as obesity and metabolic syndrome. The aims of this study were to investigate: i) 25(OH) vitamin D levels in obese patients with and without metabolic syndrome and compare these with levels in healthy subjects, ii) the relationship between serum 25(OH) vitamin D levels and metabolic syndrome components such as body mass index, waist circumference, blood pr...

Background: Laron syndrome (LS) is an autosomal recessive disease characterized by severe postnatal growth failure, short stature, normal or elevated serum GH, and low levels of IGF-I and IGF binding protein-3 (IGFBP-3). The disorder is caused by dysfunction of the growth hormone receptor resulted from mutations in GHR gene.Objective: Purpose of this research was to describe mutations on GHR gene in five children with Laron syndrome.<p class="abstext...

Introduction: Impaired fasting glucose (IFG) is defined as being present in those whose fasting blood glucose level is consistently elevated above normal, but is not high enough to be considered as having diabetes mellitus. Impaired glucose tolerance (IGT) is defined as being present in those whose second hour plasma glucose level is higher than normal, but is not high enough to be considered as having diabetes mellitus. Low serum 25-hydroxyvitamin D levels are associated with...

Introduction: Thyroid hormones play an important role in achieving and maintaining reproductive functions. Thyroid dysfunction affects the menstrual cycle and often leads to menstrual irregularity. We prospectively investigated untreated female patients presenting to our Endocrinology and Internal Medicine outpatient clinics.Material and methods: All the patients were of reproductive age and were newly diagnosed with thyroid dysfunction. After a detailed...

Rhabdomyolysis is a characterized by muscle necrosis and release of intracellular muscle constituents into the circulation. Most cases are associated with a predisposing factor such as high dose statin therapy, diabetes, old age, female gender, renal failure or hypothyroidism.An 80-year-old woman presented with severe and generalized muscle pain. Her medical history included hypertension, congestive heart failure, chronic atrial fibrillation and a thy...

Vitamin D is a lipid-soluble hormone found in certain foods and synthesized from precursors in the skin when exposed to ultraviolet light. Vitamin D plays a critical role in bone metabolism and many cellular and immunological processes; and low levels have been associated with several chronic and infectious diseases. Vitamin D status is assessed by measuring the concentration of serum 25-hydroxy vitamin D (25(OH) D). Vitamin D deficiency is reported to be common worldwide, but...

Osteoprotogerin (OPG) and the receptor activators of nuclear factor-kβ (RANK) and nuclear factor-kβ ligand (RANKL) play an important role in bone metabolism. RANKL binds to RANK, which is expressed by osteoclasts, whereas OPG acts as its decoy receptor, blocking the RANK–RANKL interaction.The aim of our study was to evaluate bone turnover parameters (serum calcium, phosphorus, alkaline phosphatase, parathormone, osteocalcine, 24-...

Background: Hashimoto’s thyroiditis is a chronic autoimmune thyroiditis. It is the most common cause of primary hypothyroidism in adolescent period, via autoimmune thyroid tissue destruction and affecting 2% of the population. In this study we want to investigate the role of the cytokines such as IL-2, IL-12, TNF-α and IFN-γ in the pathogenesis of the disease and the changes of cytokine levels with the L-thyroxine treatment....

Thyroid hormones play an important role in bone metabolism. The potential action of prolonged levothyroxine therapy on bone mass reduction is stil a matter of debate.The aim of our one year prospective study was to elucidate whether longterm suppressive thyroid hormone therapy in patient with differentiated thyroid cancer (DTC) affects bone metabolism, osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kβ ligand (sRANK-L) and is ...

Preterm labour is a serious clinical problem in obstetrics, and affective treatment of this condition still far from satisfactory. The purpose of this in vitro study was to examine the effects of isradipine, a calcium channel antagonist, on oxytocin-induced contractions of myometrium. Myometral strips were removed from late pregnant (18th day) Wistar rats following decapitation and placed in a jacked tissue bath containing Krebs’ solution and isometric contractions...